Loss of Conectivity with 3rd Party apps and P Drive

Our Environment is currently at SEP 12.1 RU 2 MP 2. We are in the process of migrating from SEP 11 to SEP 12. I was just made aware of the following issues.

1. Users are running and applicaiton and it seems to drop out all of a sudden, then evenutally come back.

2. The applications are 3rd Party

3. We currnetly have our SQL Servers on SEP 12 and other App Servers on SEP 11

4. We have shortcuts on the Desktops and they grey out or have a cross through them.

Please look at the Attachment.

Any suggestions would be appreciated. I will follow up with Symantec on this, but I want to get some feedback before I do.

All Clients have AV/NTP(Without FW)PTP.

We also have a large number of Exceptions in our Policy.