Can SEPM 12.1.2015.2015 manage client of 12.1 RU4 or RU5

Our SEPM version is of 12.1.2015.2015, can it manage the SEP client of version 12.1 RU4 or RU5? Any problem or difference?

We are using LUA server to download definition, do we need to create a new set distribution job for these clients?

Thank you~